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Estimation of the minimum effective dose of phenylephrine for treatment of hypotension after Combined Spinal and Epidural Anesthesia in elective cesarean delivery using the continual reassessment method

Estimation of the minimum effective dose of phenylephrine for treatment of hypotension after Combined Spinal and Epidural Anesthesia in elective cesarean delivery using the continual reassessment method

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ONC-12002702
Enrollment
Unknown
Registered
2012-11-14
Start date
2011-06-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of hypotension after Combined Spinal and Epidural Anesthesia in elective cesarean delivery

Interventions

Group 1:Intravenous phenylephrine 60ug
Group 2:Intravenous phenylephrine 100ug
Group 3:Intravenous phenylephrine 120ug
Group 4:Intravenous phenylephrine 120ug
Group 5:Intravenous phenylephrine 100ug
Group 6:Intravenous phenylephrine 120ug
Group 7:Intravenous phenylephrine 120ug
Group 8:Intravenous phenylephrine 120ug

Sponsors

West China Second University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
23 Years to 41 Years

Inclusion criteria

Inclusion criteria: 37-42 weeks of pregnancy; American Society of Anesthesiologists physical status I or II; single ton pregnancy; nonlaboring women undergoing an elective cesarean delivery; Spinal anesthesia after heart rate is faster than the heart rate before anesthesia.

Exclusion criteria

Exclusion criteria: 1. morbid obesity (body mass index >=40Kg/m2); 2. height140mmHg or diastolic blood pressure >90mmHg) and/or requirement for antihypertensive treatment or presence of significant proteinuria); 4. significant maternal cardiac disease or diabetes; 5. women with lumbar epidural anesthesia contraindications and/or the use of phenylephrine contraindications.

Design outcomes

Primary

MeasureTime frame
Effectively increase blood pressure( Effective/ In;

Secondary

MeasureTime frame
Umbilical cord blood blood gas analysis;Apgar score;Anesthesia - childbirth interval hemodynamic chang;

Countries

China

Contacts

Public ContactXuemei Lin
Xuemeiln@gmail.com+86 13808038449

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026