Nasopharyngeal Carcinoma
Conditions
Interventions
1:neoadjuvant chemotherapy of gemcitabine combined with cisplatin, concurrent chemotherapy of gemcitabine and IMRT
Sponsors
Nasopharyngeal Carcinoma Department of Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. pathologically confirmed or clinical diagnosis of recurrent nasopharyngeal carcinoma; 2. Intervals over 12 months from the first course radiotherapy; 3. aged 18 to 65 years old; 4. ECOG0~2; 5. at least one measurable lesion (RECIST 1.1); 6. without serious dysfunction of heart, lung, liver, kidney or other organ dysfunction; 7. Laboratory parameters: Bone marrow function: WBC>=4.0*10^9/L, ANC>=1.5*10^9/L; PLT >=100*10^9/L; HB>=90g/L; Hepatic function: ALT and AST=60ml/min.
Exclusion criteria
Exclusion criteria: 1. pathologically confirmed or clinical diagnosis of recurrent nasopharyngeal carcinoma; 2. Intervals over 12 months from the first course radiotherapy; 3. aged 18 to 65 years old; 4. ECOG0~2; 5. at least one measurable lesion (RECIST 1.1); 6. without serious dysfunction of heart, lung, liver, kidney or other organ dysfunction; 7. Laboratory parameters: Bone marrow function: WBC>=4.0*10^9/L, ANC>=1.5*10^9/L; PLT >=100*10^9/L; HB>=90g/L; Hepatic function: ALT and AST=60ml/min.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate;Overall survival;safety; | — |
Countries
China
Contacts
Public ContactGuo Xiang
Outcome results
None listed