Patients with abdominal cancers who need surgery and use sufentanil for postoperative analgesiause
Conditions
Interventions
Total:genotyping
Sponsors
Hunan Provincial Tumor Hospital (Xiangya Tumor Hospital, Central South University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. at least 18 years old, and BMI is within +/-20% of the normal range; 2. have abdominal cancers, need surgery treatment, and agree to use sufentanil for postoperative analgesia; 3. Patient or their guardians agree to participant the study, and has signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. preoperative history of chronic pain; neuropsychiatric disorders, can not correctly understand the pain scoring rules; 2. severe cardiovascular diseases, kidney or liver dysfunction, diabetes, pregnancy or breast-feeding; 3. alcoholism, opiate addiction,or long-term use of analgesic medication; 4. preoperative drug (7 days) or food history (3 days) that could induce or inhibit CYP3A4 enzyme expression. The drugs and food include: erythromycin, clarithromycin, alcohol, chocolate, caffeine, soft drink containing grape juice, verapamil, rifampicin, phenytoin,itraconazole, dexamethasone, phenobarbital, and carbamazepine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CYP3A4;ABCB1;OPRM1; | — |
Countries
China
Contacts
Public ContactJing-Shi Liu
Outcome results
None listed