Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Water Extract of Ling Zhi in Thai Male Patients with Advanced Liver Cancer

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-ONC-12002175

Enrollment

Unknown

Registered

2012-05-14

Start date

2012-06-14

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cancer

Interventions

1:Water extract of Ling Zhi

Eligibility

Sex/Gender

Male

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: All participants must have these following conditions: 1. Thai male 18-75 year of age 2. Diagnosed with advance liver cancer (can not be treated with surgery) 3. Eastern Cooperation Oncology Group performance status 0 - 2 4. Normal function of vital organs and bone marrow Hb > 10 g/dl WBC > 3.0 x 10 power 9/L neutrophil > 1.5 x 10 power 9/L platelets > 75 x 10 power 9/L AST, ALT, ALP and bilirubin are no more than two times the standard levels creatinine less than 1.5 mg/dl 5. Sign the written consent form to participate in the study and comply with the requirements of this research study

Exclusion criteria

Exclusion criteria: Patients must not have the following disease or condtions: 1. Allergic to Ling Zhi 2. Treated with chemotherapy or other types of herbal medicine 3. Severe underlying diseases such as heart failure or renal failure

Design outcomes

Primary

Measure	Time frame
Pharmacokinetic of Ling Zh;	—

Countries

Thailand

Contacts

Public ContactAssoc. Prof. Dr. Supanimit Teekachunhatean

steekach@med.cmu.ac.th+66 0 53945353

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026