Impact of host genetic polymorphism on occurrence and development of liver cirrhosis and liver cancer induced by hepatitis virus B infection

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-ONC-09000439

Enrollment

Unknown

Registered

2009-06-26

Start date

2009-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis virus B infection

Interventions

Total:Candidate genes (such as RNA helicase DDX5) are selected based on published genetic data and functional study of related proteins. Single nucleotide polymorphisms of Chinese are tested to establ

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. With one or several serum/plasm markers for hepatitis B virus infection. The markers used include hepatitis B surface antigen,hepatitis B e antigen, hepatitis B e antibody,hepatitis B core antibody, hepatitis B virus DNA and Pre-S1 antigen; 2. The participants could present as non-active hepatitis B virus carriers, chronic hepatitis B, liver fibrosis and cirrhosis, primary liver cancer or restoration after infection; 3. Able and willing to provide signed informed consent and be followed up; 4. Male and female aged 18 to 80 years old.

Exclusion criteria

Exclusion criteria: 1. Patients of chronic hepatitis C, autoimmune liver diseases, genetic and metabolic liver diseases and drug-induced liver disease; 2. Patients with serious clinical condition of other organs except the liver which may lead to liver injury.

Design outcomes

Primary

Measure	Time frame
cirrhosis and cancer risk score;Single nucleotide polymorphism;	—

Contacts

Public ContactJinsheng Guo

guo.jinsheng@zs-hospital.sh.cn+86 1366 1670 419

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026