port wine stain
Conditions
Interventions
Observation group:Hemoporfin Photodynamic Therapy
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
1 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. clinical diagnosis of PWS patients; 2. patients aged 1~65 years; 3.The subjects instructions have been read, willing and able to respond to the requirements of the program and receive follow-up visits; 4. Agree to sign written informed consent;
Exclusion criteria
Exclusion criteria: 1. The affected area is accompanied by other obvious skin diseases that may affect efficacy such as severe acne,contact dermatitis and pyogenic infection; 2. The treatment area was treated with isotope therapy, photodynamic therapy, or other treatments that might affect efficacy evaluation; 3. Currently suffering from allergic diseases; Known to suffer from skin allergies, light porphyria patients or known to test drug (porphyrin) and its chemical structure is similar to drug allergy; 4. person who has a scar constitution or has a tendency to scar; 5. Within 1 months of application of photosensitive drug known as griseofulvin, thiazide diuretics, sulfonylurea, phenothiazine, sulfa drugs, vitamin A acid, quinolones and tetracyclines in patients; 6. Known as severe immune dysfunction, or the need for long-term use of glucocorticoids and immunosuppressive agents; 7. Electrocardiographic abnormalities, organic heart disease; 8. Abnormal liver function (ALT and AST exceeded the normal value limit, TBIL exceeded 1.5 times the normal value limit) or severe renal dysfunction (renal function index exceeded the normal value of 1.5 times the upper limit); 9. One who has inherited or acquired coagulopathy or who is taking anticoagulant drugs; 10. Suffering from serious neurological, mental and endocrine disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog pain score;Investigators' subjective assessment;Patients' subjective assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| skin thickness;hyporchoic band thickness;Adler grade of blood flow;shearwave velocity;Young's modulus;Vascular density; | — |
Countries
China
Contacts
Public ContactJiang Xian
West China Hospital, Sichuan University
Outcome results
None listed