Nasopharyngeal carcinoma
Conditions
Interventions
1:5 - fluorouracilcapecitabine in combination with cisplatin synchronous intensity-modulated radiotherapy (CCRT)
2:capecitabine in combination with cisplatin synchronous intensity-modulated radiotherapy(CCRT)
Sponsors
The Second People's Hospital of Neijiang
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. By pathological or cytological diagnosis of nasopharyngeal carcinoma patients and treated first; 2. UICC2003 stage for III, a and bIV IV (local middle-late); 3. Without radiation and chemotherapy absolute contraindications; 4. Signed informed consent before treatment; 5. Aged 18 to 80 years old, physical status ECOG 0 ~ 2 or KPS acuity 70; 6. Subjects were no vital organ dysfunction, routine blood, lung, liver, kidney, blood coagulation function and cardiac function were all normal; 7. Patients who had good compliance treatment and follow-up.
Exclusion criteria
Exclusion criteria: 1. Do not accord with the standard set of staging and survival of patients; 2. Nasopharyngeal carcinoma recurrence after chemotherapy; patient who ever accept any form of external andcavities beam radiation therapy; 3. patient with high blood pressure, diabetes, history of unstable angina pectoris can't be controlde and history of myocardial infarction, or seen in the past 12 months have symptoms of congestive heart failure or unable to control arrhythmia;Electrocardiogram (ecg) prompt a ischemic change or clinical diagnosis of heart valve disease; Bacteria, fungi or viruses infection disease activity; Mental disorders; 4. Patients with pregnancy or lactation; 5. With allergic constitution and known or suspected patients allergic to any drugs applyde to research 6. Poor compliance of patients; 7. Researchers think that is unfavorable to the subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| local control rate;side effect; | — |
Countries
China
Contacts
Public ContactDu Chi
The Second People's Hospital of Neijiang
Outcome results
None listed