hand, foot and mouth disease
Conditions
Interventions
rhIFNa2b Group:rhIFNa2b spray
ribavirin group:ribavirin spray
Sponsors
Beijing Ditan Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 7 Years
Inclusion criteria
Inclusion criteria: (1) in accordance with the ministry of health "hand-foot-mouth disease diagnosis and treatment guidelines, 2010" diagnostic criteria of HFMD patients in period I; (2) aged 1-7 years old boys and girls; (3) within 48 hours; (4) no antiviral drugs were used in the previous course of the group; (5) main organs (heart, liver and kidney) have normal functions; (6) the patient carefully read the informed consent and volunteered to participate in the project.;Inclusion criteria: (1) in accordance with the ministry of health "hand-foot-mouth disease diagnosis and treatment guidelines, 2010" diagnostic criteria of HFMD patients in period I; (2) aged 1-7 years old boys and girls; (3) within 48 hours; (4) no antiviral drugs were used in the previous course of the group; (5) main organs (heart, liver and kidney) have normal functions; (6) the patient carefully read the informed consent and volunteered to participate in the project.;Inclusion criteria: (1) in accordance with the ministry of health "hand-foot-mouth disease diagnosis and treatment guidelines, 2010" diagnostic criteria of HFMD patients in period I; (2) aged 1-7 years old boys and girls; (3) within 48 hours; (4) no antiviral drugs were used in the previous course of the group; (5) main organs (heart, liver and kidney) have normal functions; (6) the patient carefully read the informed consent and volunteered to participate in the project.;Inclusion criteria: (1) in accordance with the ministry of health "hand-foot-mouth disease diagnosis and treatment guidelines, 2010" diagnostic criteria of HFMD patients in period I; (2) aged 1-7 years old boys and girls; (3) within 48 hours; (4) no antiviral drugs were used in the previous course of the group; (5) main organs (heart, liver and kidney) have normal functions; (6) the patient carefully read the informed consent and volunteered to participate in the project.;Inclusion criteria: (1) in accordance with the ministry of health "hand-foot-mouth disease diagnosis and treatment guidelines, 2010" diagnostic criteria of HFMD patients in period I; (2) aged 1-7 years old boys and girls; (3) within 48 hours; (4) no antiviral drugs were used in the previous course of the group; (5) main organs (heart, liver and kidney) have normal functions; (6) the patient carefully read the informed consent and volunteered to participate in the project.
Exclusion criteria
Exclusion criteria: (1) history of interferon allergy; (2) severe hand-foot-mouth disease; (3) other antiviral drugs (such as ribavirin, acyclovir, etc.) have been used; (4) there are other serious diseases such as cardiac insufficiency, respiratory insufficiency, hepatic and renal insufficiency and severe malnutrition; (5) having epilepsy or other central nervous system dysfunction; (6) the researcher considers it inappropriate to participate in this experiment.;Exclusion criteria: (1) history of interferon allergy; (2) severe hand-foot-mouth disease; (3) other antiviral drugs (such as ribavirin, acyclovir, etc.) have been used; (4) there are other serious diseases such as cardiac insufficiency, respiratory insufficiency, hepatic and renal insufficiency and severe malnutrition; (5) having epilepsy or other central nervous system dysfunction; (6) the researcher considers it inappropriate to participate in this experiment.;Exclusion criteria: (1) history of interferon allergy; (2) severe hand-foot-mouth disease; (3) other antiviral drugs (such as ribavirin, acyclovir, etc.) have been used; (4) there are other serious diseases such as cardiac insufficiency, respiratory insufficiency, hepatic and renal insufficiency and severe malnutrition; (5) having epilepsy or other central nervous system dysfunction; (6) the researcher considers it inappropriate to participate in this experiment.;Exclusion criteria: (1) history of interferon allergy; (2) severe hand-foot-mouth disease; (3) other antiviral drugs (such as ribavirin, acyclovir, etc.) have been used; (4) there are other serious diseases such as cardiac insufficiency, respiratory insufficiency, hepatic and renal insufficiency and severe malnutrition; (5) having epilepsy or other central nervous system dysfunction; (6) the researcher considers it inappropriate to participate in this experiment.;Exclusion criteria: (1) history of interferon allergy; (2) severe hand-foot-mouth disease; (3) other antiviral drugs (such as ribavirin, acyclovir, etc.) have been used; (4) there are other serious diseases such as cardiac insufficiency, respiratory insufficiency, hepatic and renal insufficiency and severe malnutrition; (5) having epilepsy or other central nervous system dysfunction; (6) the researcher considers it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total efficiency ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The disappearance time of fever;the appetite improvement ; the disappearance times of oral herpes; the disappearance times of rash; | — |
Countries
China
Contacts
Public ContactXingwang Li;Xingwang Li;Xingwang Li;Xingwang Li;Xingwang Li ;;;;
Beijing Ditan Hospital, Capital Medical University;Beijing Ditan Hospital, Capital Medical University;Beijing Ditan Hospital, Capital Medical University;Beijing Ditan Hospital, Capital Medical University;Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed