allergic rhinitis and/or asthma caused by HDM sensitize
Conditions
Interventions
Study group:HDM Alutard AIT
Control group:Symptomatic allergy medication only
Sponsors
The Second People's Hospital of Wuhu
Eligibility
Sex/Gender
All
Age
5 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged 5-55 year; 2. Patient with mild to moderate persistent HDM allergic rhinitis (with or without asthma); 3. Positive Skin Prick Test (SPT) response (wheal index SI = 0.5) to Dermatophagoides pteronyssinus.
Exclusion criteria
Exclusion criteria: 1. PEF < 70% of predicted value; 2. Requirement of inhaled or systemic corticosteroid therapy for asthma symptoms during the screening period, with a daily dosage of beclomethasone dipropionate 800ug, or regular oral intake of prednisone; 3. Current symptoms or treatment of ongoing upper respiratory tract infection, acute sinusitis, acute otitis media or other relevant infectious process; 4. AIT treatment with house dust mite allergens or other allergen within the last 5 years; 5. Any diagnosis of underlying disease in heart, lung, liver, kidney, or blood, etc.; 6. Patient is under treatment with ß-blocker; 7. Patient with immune defects / deficiencies, or in immunosuppressive treatment; 8. Allergy, hypersensitivity or intolerance to any of the first aid medicines; 9. Any mental condition rendering the patient unable to understand the nature, scope and possible consequences of the trial, and/or evidence of an uncooperative attitude; 10. Unlikely to be able to complete the trial, for any reason, or likely to move, or travel for extended periods of time during the trial period; 11. Subjects shouldn't meets any of the exclusion criteria listed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rhinitis symptoms;Asthma symptoms;Medications on AR;Medications on asthma;Juniper's RQLQ;Juniper's AQLQ;Der p, Der p 1, Der p 2 specific IgE in serum;Der p, Der p 1, Der p 2 specific IgG4 in serum;Der p, Der p 1, Der p 2 specific IgG4 in saliva; | — |
Countries
China
Contacts
Public ContactXiaozhong Gui
The Second People's Hospital of Wuhu
Outcome results
None listed