lymphoplasmacytic lymphoma / Waldenstrom macroglobulinemia
Conditions
Interventions
1:autologous stem cell transplatation
Sponsors
Institute of Hematology Blood Disease Hospital, Chinese Academy of Medical Sciences Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. diagnosed with high-risk LPL/WM according to the ISSWM criteria; 3. Untreated or mild treated without standard regimens; 4. suitable for ASCT; 5. with life-expectary more than 3 months.
Exclusion criteria
Exclusion criteria: 1. diagnosed with other malignancies outside B-NHL within one year(including active centre neural system lymphoma); 2. Transformed lymphoma; 3. liver or renal funcation lesion unrelated to lymphoma; 4. serious complications such as uncontroled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician; 5. HIV positive or active HBV infection or other uncontroled systematic infection; 6. clincial central nervous dysfunction; 7. serious surgery within 30 days; 8. pregnancy or baby nursing period or uncontracept child-bearing period woman; 9. allergy to the trail drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;complete remission rate;duration of remission interval; | — |
Countries
China
Contacts
Public ContactShuhua Yi
Institute of Hematology Blood Disease Hospital, Chinese Academy of Medical Sciences Peking Union Medical College
Outcome results
None listed