Acute ST segment elevation myocardial infarction
Conditions
Interventions
Intervention gro:Intravenous administration of recombinant human urokinase (Pu Youke)
Sponsors
The Second Hospital Affiliated to Tianjin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) severe persistent chest pain more than 30 minutes or more, can not alleviate the symptoms; (2) 2 adjacent or above 2 ST elevation, in limb leads more than 0.lmV, more than 0.2mV chest lead; (3) the proposed on to thrombolysis time less than 6 hours; (4) 18-75 years old, aged above 75 years old unable to accept PCI, as appropriate, the use of reduction; (5) patients / or their families are willing to take part in this experiment agree to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) currently in use of anticoagulants; (2) there is a history of bleeding, trauma, internal organs (including biopsy) in a month, or at present, there is an active peptic ulcer disease; (3) with traumatic cardiopulmonary resuscitation (traumatic CPR is equal to or more than 10 minutes), 2 weeks had not implementation of the compressed blood vessel puncture had a history of trauma; (4) in patients with essential hypertension after active antihypertensive therapy, blood pressure is greater than or equal to 180/110mmHg persons (tolic blood pressure, diastolic blood pressure either one reached the standard for blood pressure); (5) suspected aortic dissection, infective endocarditis, can not be excluded the preceding diagnosis; (6) cardiac shock or severe left heart failure pulmonary edema after expansion use of vasoactive drugs; (7) previous cerebral hemorrhage, hemorrhagic stroke, or subarachnoid hemorrhage. There are other stroke or cerebral vascular events (including TIA), known intracranial tumors, cerebral vascular malformations in 6 months; (8) there is a bleeding retinal history; (9) a variety of hematologic diseases, bleeding disorders or bleeding tendencies; (10) patients with severe liver kidney dysfunction, severe depletion of state, or malignancy; (11) female pregnancy; (12) patients / or their families are not willing to take part in this experiment, not willing to sign the informed consent; (13) doctors believe that other conditions are not suitable for intravenous thrombolysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical opening rate;Coronary patency rate; | — |
Countries
China
Contacts
Public ContactLi Guangping
The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed