Acute leukemia
Conditions
Interventions
one:conditioning including idarubicin and antithymocyte globulin
Sponsors
The First Affilited Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Standard-risk acute leukemia; 2. Age: 18 to 40 years old; Gender: Male or female; 3. Patients in the first complete remission(CR1); 4. HLA-matched or one allele mismatched sibling donor allogeneic hematopoietic stem cell transplantation; 5. In good general condition, ECOG score less than 1; 6. Enrolled patients signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Cardiac dysfunction (ejection fraction less than 60%); Lung function insufficiency(obstruction and/or restrictive ventilatory disorders); Hepatic dysfunction (total bilirubin more than 34umol/L, ALTAST more than 2 times the upper limit of normal); Renal insufficiency (serum creatinine more than 130umol/L); 2. Severe invasive fungal infections uncontrolled before transplantation; 3. Contraindicated in using IDA, IDA total cumulative dose up to 300 mg/m2; 4. Severe allergic on Antithymocyte globulin (anaphylactic shock or laryngeal edema); 5. Unrelated donor or autologous allogeneic hematopoietic stem cell transplantation; reduced-intensity conditioning transplantation; 6. Other circumstances which do not meet the inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the relapse of leukemia post-transplantation;graft-versus-host disease post-transplantation;2-years OS post-transplantation;2-years DFS post-tansplantation; | — |
Countries
China
Contacts
Public ContactYongrong Lai
Outcome results
None listed