Recurrence Hepatocellular carcinoma
Conditions
Interventions
Treatment group:EpCAM CART
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients should meet the following criteria to participate in the experiment: 1. have signed informed consent; 2. aged 18 to 75 years male and female; 3. hepatocellular carcinoma recurrence after resection or liver transplantation, no radical resection indications, only through interventional treatment of patients; 4. after resection of postoperative pathology immunohistochemistry confirmed pathologic diagnosis of hepatocellular carcinoma tumor immunohistochemistry suggestive EpCAM (+), adjacent tissue suggestive EpCAM (-); 5. Liver function child A level, before the group of conventional blood tips white blood cell count within the normal range, coagulation function is normal; 6. tumor characteristics can meet any of the following conditions: (1) postoperative liver recurrence to meet BCLC B, (more than a single greater than 5cm, 2-3 more than 3cm standard), may or may not be associated with distant metastasis; (2) patients are reluctant to continue surgery; (3) diffuse liver cancer.
Exclusion criteria
Exclusion criteria: Patients may be excluded from this study if they meet one of the following criteria: 1. with other malignancies; 2. patients are using antineoplastic agents and any other research drugs within 2 weeks of the same period; 3. patients with central nervous system Disease, mental illness, unstable angina, congestive heart failure, severe arrhythmia or other uncontrollable serious illness; 4. patient history of drug or similar structural allergy; 5. pregnancy, breastfeeding or urine pregnancy test Positive; 6. baseline examination of serious infection, bleeding, liver dysfunction or other postoperative complications and life-threatening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective remission rate; | — |
Countries
China
Contacts
Public ContactJiayin Yang
West China Hospital, Sichuan University
Outcome results
None listed