knee osteoarthritis
Conditions
Interventions
Case series:Intra-articular and extra-articular Platelet Rich Plasma injections 6 ml PRP plus 1 ml of 1% xylocaine (total 7 ml), once, single injection
Sponsors
The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Aged 45 to 75 years old; 2) Self-reported symptoms consistent with KOA per American College of Rheumatology guidelines; 3) Have experienced moderate to severe knee pain for at least 3 months, defined as a score of 3 or more (0-6 ordinal response scale) on the question "What is the average level of your left/right knee pain?" 4) Failed 6 months of usual care; 5) Clinical evidence of KOA according to the American College of Rheumatology guidelines; 6) Radiographic evidence of KOA with Kellgren Lawerance (KL).
Exclusion criteria
Exclusion criteria: 1) Pregnancy; 2) On anticoagulation, immunosuppressive or daily opioid therapy; 3) History of collagen tissue or other autoimmune disorders; 4) Hematological diseases; 5) Severe cardiovascular diseases; 6) Prior or planned total knee replacement of the affected knee; 7) Allergy or intolerance to acetaminophen or xylocaine; 8) Body mass index (BMI) = 35 kg/m2; 9) Co-morbidity severe enough to prevent reliable or safe study participation; 10) Subjects who cannot read or write in the Chinese Consent form; 11) Interim knee joint infectious arthritis or trauma; 12) Hemoglobin level < 11g/dL; 13) Platelet concentration < 150,000/mm3; 14) Clinical examination suggesting that the patient is not appropriate due to comorbid knee or other conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility measurements;Safety of the intervention; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective functional outcomes;Self-reported knee-specific pain, function and stiffness;Health-related quality of life;Treatment satisfaction;Analgesics consumption;Acute and Constant Knee Pain Severity; | — |
Countries
China
Contacts
Public ContactRegina Wing Shan SIT
Division of Family Medicine and Primary Health Care, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong
Outcome results
None listed