ovarian cancer
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. female patients with age of 18–70 years old; 2. histologically confirmed cervical squamous cell carcinoma or epithelial ovarian carcinoma; 3. Computed tomography, magnetic resonance image or positron emission tomography confirmed advanced or recurrent disease; 4. had at least three lines of chemotherapy fail before participating in the study and at least 4 weeks after last chemotherapy; 5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; 6. at least one measurable lesion according to Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 criteria; (?) Appropriate hematologic, coagulation, hepatic and renal function (hemoglobin = 90g/L, platelet > 80 x 10^9/L, neutrophil count > 1.5 x 10^9/L, serum creatinine =1x upper limit of normal (ULN), bilirubin =1.25 x ULN, ) international normalized ratio (INR) =1.5, and activated partial thromboplastin time (APTT) < 1.5 x ULN).
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating female patients; 2. prior history of other malignancies or antiangiogenic therapy; 3. uncontrolled high blood pressure with medication (> 140/90 mmHg); 4. receiving thrombolytics or anticoagulants therapy; 5. existing active bleeding, ulcer, intestinal perforation, intestinal obstruction, unhealed wound or fracture; 6. urine protein = 2+ or 24 hours total urinary protein > 1.0 g; 7. simultaneously receiving any anti-tumor therapy; 8. less than 4 weeks after last clinical trial; 9. symptomatic central nervous system metastases or carcinomatous meningitis; 10. suffering severe pulmonary or cardiac disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Disease control rates;Objective response rate; | — |
Countries
China
Contacts
Public ContactXie Congying
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed