acute promyelocytic leukemia
Conditions
Interventions
APL:Realgar-indigo naturalisformular
Sponsors
Tianjin Hematonosis Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 16 Years
Inclusion criteria
Inclusion criteria: Patients should meet the following three requirements at the same time: 1. Diagnosis of acute promyelocytic leukemia by morphology; 2. PML-RARA fusion gene positive and /or carry chromosomal translocation t(15;17); 3. Aged 20 days to 18 years.
Exclusion criteria
Exclusion criteria: 1. Reccurence or secondary neoplasmia; 2. Secondary to immunodeficiency disease,bone marrow failure or other congenital defect; 3. Participants with prior therapy of ATRA or arsenic over 1 week; 4. Participants with prior therapy of cytotoxic agents; 5. Participants with complications not secondary to APL and researchers concluded that need to rule out; 6. Participants without Guardian Informed Consent Agreement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone marrow morphology;Bone marrow fusion gene test;event free survival;overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone marrow Karyotype;FISH translocations;Peripheral blood blast cell count;Bone marrow immunophenotype;Electrocardiogram;blood Electrolytes;Blood chemistry;Coagulation;Drug monitoring;Hematology;Cerebralspinal Fluid test;Toxicity;Surgical cases due to complications;Urinalysis;Stool test; | — |
Countries
China
Contacts
Public ContactZHU Xiaofan
Tianjin Hematonosis Hospital
Outcome results
None listed