Massive hepatocellular carcinoma
Conditions
Interventions
group A:alternating intensity modulated radiotherapy
group B:intensity modulated radiotherapy
Sponsors
The Fifth Hospital of Wuhan (Wuhan Cancer Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients of unresectable advanced stage massive HCC are discussed by multidisciplinary team (including at least one hepatic surgeon). Lesion is confirmed by image examinations and its volume must be smaller than 2/3 of the liver volume; age=18 years; KPS=70 before registered two weeks ago; Bone marrow hematopoietic function tests before entered group two weeks ago, including: WBC=1.5×10^9/L, PLT=100×10^9/L; HGB=10.0 g/dl (HGB=10.0 g/dl under the supportive therapy is accepted), SCR or CCR=60 ml/min,Child-Pugh A or B, ALT<90U/L; AST<90U/L, TBil<160umol/L.
Exclusion criteria
Exclusion criteria: Patients were accepted abdominal radiotherapy or potential radiation fields overlap due to radiation therapy; A large number of peritoneal effusion suggested by color ultrasound; intrahepatic metastasis; metastasis in other distant organs; fertile female and male who are not willing to contracept; patients are not suitable to enhance contrast MRI or CT examinations (cardiac pacemaker, allege to enhance contract agents and so forth); unstable angina pectoris and /or chronic congestive heart-failure happened within six months; transmural myocardial infarction happened in six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical benefit rate;overall survival rate;objective response rate;local control rates;local control rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival;Alpha-fetoprotein; | — |
Countries
China
Contacts
Public ContactLong Zhixiong
The Fifth Hospital of Wuhan (Wuhan Cancer Hospital)
Outcome results
None listed