Effect of smoking on drug efficacy of muscle relaxation
Conditions
Interventions
Smokers and non-smokers cohorts:vecuronium
Sponsors
Department of anesthesia, the Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male patients undergoing abdominal surgery to be ASA, I or II grade, age 20 to 50 years old, 18.5 BMI < 24, airway Mallampati grade I ~ II grade. The routine examination of heart, lung, liver and kidney function is normal, without neuromuscular disease, no pathological obesity, no serious anemia and malnutrition, no electrolyte and acid-base imbalance, preoperative drug history also did not take effect of neuromuscular function. No history of drug allergy. The operative time ranged from 1 to 2 hours. Understand the informed consent, and agreed to sign in the study before informed consent.
Exclusion criteria
Exclusion criteria: The routine examination of heart, lung, liver and kidney dysfunction, neuromuscular disease, pathological obesity, severe anemia and malnutrition and electrolyte imbalance and acid-base imbalance, a history of drug effects of neuromuscular function taking before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clinical effect of vecuronium in time;index of recovery;The dosage of vecuronium;General situation of patients; | — |
Countries
China
Contacts
Public ContactZhou Xiaohua
the Affiliated Hospital of Guizhou Medical University
Outcome results
None listed