Chronic Pain After Major Breast Cancer Surgery. A Retrospective Analysis of Single-injection Versus Multiple-injection of Thoracic Paravertebral Block

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OIC-15007385

Enrollment

Unknown

Registered

2015-11-10

Start date

2015-11-23

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Interventions

Case series:This is a retrospective study reviewing clinical records of two groups of patients who previously had received thoracic paravertebral block (TPVB), either single or multiple injection, as

(to be continued):Data recorded from the Clinical Management System (patient database of Hospital Authority) will include anaesthetic records and postoperative treatment data (i.e. radiotherapy, chemo

(to be continued):and the pain intensity, characteristics, and the incidence of chronic pain at postoperative 3 months from our previous studies CRE-2004.376-T (single injection of TPVB) and CRE-2013.

(to be continued):No direct patient contact and no intervention will be performed. The result obtained will only serve as pilot data to generate hypothesis for future prospective randomized study if m

Eligibility

Sex/Gender

Female

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients who had general anaesthesia and single injection of TPVB from our previous study (CRE-2004.376-T) will serve as the control group in this study. Patients who had multiple-injection of TPVB without pectoral nerve block for major breast cancer surgery including subjects of our on-going study (CRE-2013.497) will be selected. Only patients with similar demographics including age, body mass index, and American Society of Anesthesiologists (ASA) Physical Classification System, and postoperative treatment data (i.e. Radiotherapy, chemotherapy, and/or endocrine therapy) of both single-injection of TPVB and multiple-injection of TPVB will be included to ensure both groups are comparable before doing data analysis.

Exclusion criteria

Exclusion criteria: Patients who had chemotherapy before surgery (neoadjuvant chemotherapy) as this can cause neuropathic changes and inflict pain. Patients who had a pectoral nerve block inn addition to the multiple-injection of TPVB will be excluded.

Design outcomes

Primary

Measure	Time frame
The incidence of chronic pain at 3 months after major breast cancer surgery, 3 months after major breast cancer surgery;	—

Secondary

Measure	Time frame
Pain intensity and characteristics, 3 months postoperative;	—

Countries

China

Contacts

Public ContactManoj Kumar Karmakar

karmakar@cuhk.edu.hk+852 2632 1311 / 2735

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026