septic shock
Conditions
Interventions
Gold Standard:
Index test:
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
19 Years to 85 Years
Inclusion criteria
Inclusion criteria: having septic shock and ALI, being on mechanical ventilation with a tidal volume of at least 8 ml kg1 without any spontaneous breathing efforts as detected by continuous air-way pressure and flow monitoring on the ventilator screen.The definition for septic shock as defined by the International Sepsis Definitions Conference: 1. Two or more of the following four items: (1) Temperature >38.3 degree C or 4 mmol/L.The definition for ALI for this investigation was based on the American-European Consensus definition and defined as bilateral infiltrates on the chest radiograph, acute onset of respiratory failure requiring mechanical ventilation, PaO2/FiO2 ratio< 300mm Hg, and a pulmonary artery occlusion pressure 18 mmHg, or no evidence of left atrial hypertension.
Exclusion criteria
Exclusion criteria: Patients were excluded if their chest radiographs were compatible with acute pulmonary oedema, cardiac arrhythmia (atrial fibrillation or frequent premature beats), severe peripheral vascular disease and left ventricular ejection fraction less than 40%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| global end-diastolic volume index (GEDVI), pulse pressure variation (PPV), stroke volume variation; | — |
Countries
China
Contacts
Public ContactZhen Riqiang
Outcome results
None listed