Addiction
Conditions
Interventions
all subjects:deep brain stimulation
Sponsors
101th Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-50 years old male or female; 2. complied with the condition ICD-10 diagnostic criteria for opioid dependence; 3. opioid dependence over the course of three years, at least three times more than the use of the system non-surgical therapy drug treatment. Ineffective treatment, the end result of the persistence of psychological dependence on the drug, leading to difficult to overcome relapse; 4. the general physical condition is still good, no severe liver, kidney, heart and lung disease; 5. no significant damage to mental disorders, personality disorders, psychosocial function; 6. No major infectious diseases such as AIDS and syphilis; 7. has completed the physiological detoxification treatment (already out and substitute methadone and other drugs at least 7-10 days, acute withdrawal symptoms disappeared, urine morphine, naloxone reminder addiction test was negative), no withdrawal symptoms; 8. patients themselves and their immediate families have a detailed understanding of the operation of purpose, meaning, efficacy, complications and risk can voluntarily requested surgery; 9. good compliance, patients and their families have to participate in "deep brain stimulation to prevent opioid dependence after withdrawal relapse will "clinical trials, and to regular follow-up; 10. subjects signed informed consent.
Exclusion criteria
Exclusion criteria: 1. the patient himself on the dangers of drug taking lack of knowledge, not offered himself voluntarily requested drug, but forced from social pressure or friends and relatives; 2. severe cognitive impairment (MMSE score: illiteracy <17, primary school <20 junior high school or <24) because crazy Effect stay subject poor compliance, and / or unable to sign an informed consent form; 3. there is a history of severe mental illness; 4. with active epilepsy (ie, seizures) persons; 5. there is a serious heart, liver, kidney disease and severe hypertension and severe orthostatic hypotension; 6. patients with severe diabetes or severe heart and cerebrovascular diseases; 7. diagnosed cancer patients; 8. surgical contraindications (such as cochlear implants too, pacemakers, cardiac defibrillators, stereotactic God After lesion in, who had unilateral or bilateral implantation of similar products, etc.) or within six months, researchers did recognize. For other surgical procedures of the trial were influential, or other neurosurgical contraindication; 9. have suffered traumatic brain injury nervous system; 10. are taking anticoagulants or clinical bleeding tendencies; 12. patients are participating in other clinical trials, or within three months of receiving the other clinical studies; 13. The researchers consider it appropriate to participate in this clinical investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PET-CT examins the glucose metabolism; | — |
Countries
China
Contacts
Public ContactLin Wei
101th Hospital of PLA
Outcome results
None listed