sepsis
Conditions
Interventions
Case series:no
Sponsors
The first Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sepsis (1) Fever (>38.3 degree C), Hypothermia (core temperature90 min-1 or more than two SD above the normal value for age; Tachypnea; Altered mental status; Significant edema or positive fluid balance (>20 mL/kg over 24 h); Hyperglycemia (plasma glucose>140 mg/dL or 7.7 mmol/L) in the absence of diabetes; (2) Inflammatory variables:Leukocytosis (WBC count>12,000 lL-1), Leukopenia (WBC count40 mmHg in adults, or less than two SD below normal for age; (4) Organ dysfunction variables: Arterial hypoxemia (PaO2/FiO2=0.5 mg/dL or 44.2 lmol/L; Coagulation abnormalities (INR>1.5 or aPTT>60 s); Ileus (absent bowel sounds); Thrombocytopenia (platelet count4 mg/dL or 70 lmol/L); (5) Tissue perfusion variables: Hyperlactatemia (>1 mmol/L), Decreased capillary refill or mottling. Severe sepsis (1) Lactate above upper limits laboratory normal; (2) Urine output2.0 mg/dL (176.8 lmol/L); (5) Bilirubin>2 mg/dL (34.2 lmol/L); (6) Platelet count1.5). Septic shock: (1) Systolic blood pressure 40mmHg at least 1h, or dependent on infusion and drugs to maintain blood pressure, mean arterial pressure 2s; (3) cold limbs or piebald skin; (4) lactic acidosis; (5) decreased urine output (urine output <0.5 ml/kg/h, for at least two hours, even if given adequate fluid resuscitation).
Exclusion criteria
Exclusion criteria: (1) Who do not want to participate in this experimenter or their families; (2) Age <18 years; (3) A history of left ventricular dysfunction, dilated cardiomyopathy, acute coronary syndrome, acute or chronic heart valve disease, acute or chronic renal insufficiency, defibrillation, direct current cardioversion, chest trauma, chest compressions, thoracic incision, myocardial damage, cardiogenic shock, hemorrhagic shock, acute or chronic heart failure), patients with muscle injury.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Hematocrit;Potassium;Sodium;28 days Mortality;Blood platelet;Lactate;PH;PaO2;left atrial diameter (LA);Left ventricular internal diameter (LV);right atrial diameter (RA);Right ventricular internal diameter (RV);Ejection Fraction;cardiac output;stroke volume; | — |
Primary
| Measure | Time frame |
|---|---|
| Heart fatty acid binding protein;BNP;Troponin;Creatinine;APACH-II score;IL-6;Creatine kinase;Creatine kinase isoenzyme;Procalcitonin;High-sensitivity C-reactive protein; | — |
Countries
China
Contacts
Public ContactYang Jianzhong
Outcome results
None listed