Sudden Arrhythmia Death Syndromes
Conditions
Interventions
Case series:Not Applicable
Sponsors
Princess Margaret Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 40 Years
Inclusion criteria
Inclusion criteria: Index SCD Victims 1. Age 5 to 40 years; 2. Death 1 hour after onset of symptoms or within 24 hours of the victim being seen alive; 3. Negative autopsy or autopsy shows evidence of either hypertrophic or arrhythmogenic right ventricular cardiomyopathy; 4. Negative toxicological screening; 5. Informed consent obtained from their next-of-kin for a molecular autopsy in the study Relatives of index SCD Victim; All first-degree relatives who consent to undergo the clinical and genetic evaluation as described in this study protocol.
Exclusion criteria
Exclusion criteria: Index SCD Victim 1. SCD victim with genetically proven SADS Relatives of index SCD Victim 1. Pregnant women; 2. Mentally or cognitively disabled to give informed consent; 3. Unable to attend assessment clinic or clinical evaluation in PMH; 4. younger than 5 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence and types of SADS among the young SCD families in the study population identified by clinical and molecular autopsy of SCD victims and/ clinical and targeted genetic evaluation of their first-degree relatives; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Genotypes of SADS victims in the study population;2. Number of young SUD families identified with SADS by molecular autopsy;3. Number of young SUD families identified with SADS by clinical evaluation of first-degree relatives;4. Number of young SUD families identified with SADS by a combined approach;5. Pattern of inheritance of SADS and their clinical characteristics among; | — |
Countries
China
Contacts
Public ContactDr. Ngai Shing MOK
Outcome results
None listed