preterm birth
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Pregnant women who take prenatal care in Haidian District Maternal and Child Health Hospital. 1) singleton pregnancy; 2) 18-40 years old.
Exclusion criteria
Exclusion criteria: 1) induction due to fetal malformations, fetal death or unplanned pregnancy; 2) preterm birth due to explicit accident, such as trauma; 3) twins or multiple births; 4) smoking, drinking or drug addicts ( one month before pregnancy, and during pregnancy); 5) People with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus; 6) complicated with chronic disease of liver, kidney or other vital organs; 7) with severe acute or chronic diseases, such as heart disease (heart function III grade and above), diabetes, severe thyroid function hyperthyroidism or hypothyroidism, etc.; 8) with impatient, chronic infections, such as respiratory infections, arthritis, active viral hepatitis; 9) suffering from congenital diseases; 10) associated with mental disorders; 11) special medication history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mononuclear cells transcriptome;Clinical risk factors;ultrasound cervical evaluation ; | — |
Secondary
| Measure | Time frame |
|---|---|
| fetal fibronectin, fF; | — |
Countries
China