type 2 diabetes with metabolic syndrome
Conditions
Interventions
newly diagnosed type 2 diabetes with metabolic syn:Measuring physical index, blood specimens
newly diagnosed type 2 diabetes without metabolic:Measuring physical index, blood specimens
Sponsors
Department of Endocrinology, Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. T2DM subjects: The criteria of diagnosis of type 2 diabetes recommended by WHO in 1999 were adopted, these newly diagnosed T2DM subjects had fasting plasma glucose levels more than 7.0mmol/L and 2h OGTT glucose levels more than 11.1mmol/L; The diagnosis of MetS was based on the global consensus of MetS according to the 2005 International Diabetes Federation. Patients must have central obesity (Chinese standard: male waist circumference more than 90 cm, female waist circumference more than 80 cm) and any 2 of the following 4 factors to make the diagnosis: 1) TG more than 1.7 mmol/L; 2) HDL-C less than 1.03 mmol/L for men and less than 1.29 mmol/L for women; 3) increasing fasting plasma glucose (FPG more than 5.6 mmol/L); 4) high blood pressure (systolic blood pressure higher than 130 mmHg or diastolic blood pressure higher than 85 mmHg); 2. Normal control: healthy person.
Exclusion criteria
Exclusion criteria: T2DM subjects who were treated with oral hypoglycemic agents were excluded to avoid the possible confounding effects of anti-diabetic medications. T1DM, individuals with gestational diabetes, active hepatitis/liver cirrhosis, chronic renal failure on hemodialysis, congestive heart failure or other known major disease were precluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| high-molecular-weight adiponectin;OGTT;netrin-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| hs-CRP;insulin releasing test;HbA1c;BMI;blood lipid profiles;blood pressure;age; | — |
Countries
China
Contacts
Public ContactYuan Guo-yue
Outcome results
None listed