The role of bile acid receptor TGR5 in intestinal mucosal injury in patients with obstructive jaundice

The expression and role of bile acid receptor TGR5 in intestinal mucosa in patients with obstructive jaundice

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OCH-14004943

Enrollment

Unknown

Registered

2014-07-10

Start date

2014-08-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The injury of intestinal mocosa

Interventions

Healthy Control:NO

Malignant Biliary Obstruction without Jaundice:NO

Malignant Obstrucive Jaundice:Endoscopic Retrograde Biliary Drainage

Eligibility

Sex/Gender

All

Age

20 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Malignant obstructive jaundice caused by cholangiocarcinoma and pancreatic head carcinoma; 2. Bilirubin concentration exceeding 5.0 mg/dL and without signs of cholangitis.

Exclusion criteria

Exclusion criteria: 1. any previous ERCP; 2. elevated serum amylase; 3. current treatment with antibiotics; 4. pathological endoscopic findings in the upper gastrointestinal tract during ERCP; 5. concomitant systemic diseases with immunosuppression; 6. celial disease, cirrhosis, inflammatory bowel disease; 7. treatment with medications that might act on TJ regulation or apoptosis.

Design outcomes

Primary

Measure	Time frame
serum LPS;serum D-lactate;serum DAO;serum I-FABP;intestinal cell proliferation and apoptosis;tight junction protein;TGR5;	—

Countries

China

Contacts

Public ContactHuiqing Jiang

jianghq@aliyun.com+86 15803210956

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026