cerebrovascular disease
Conditions
Interventions
case series:NA
Sponsors
Department of Neurology, Affiliated Deyang Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients who were admitted within 72 hours from symptoms onset and diagnosed with ischemic stroke confirmed by brain CT or MRI; 2. the potential etiology of stroke was classified as large-artery atherosclerosis(LAA), small-artery occlusion(SAO) based on TOAST criteria.
Exclusion criteria
Exclusion criteria: 1. the potential etiology of stroke was classified as cardio-embolism(CE), stroke of other determined etiology(OC) and stroke of undetermined etiology(UND) based on TOAST criteria; 2. administration of ticlopidine, glycoprotein IIb/IIIa inhibitor nonsteroidal anti-inflammatory drugs and anticoagulant within 1 week prior to admission; 3. family or personal history of bleeding disorders; 4. platelet count 450×10^9/L; 5. other contraindications for clopidogrel; 6. recently use of PPI; 7. Patients who refused to participate in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| platelet aggregation testing;ABCB1 gene: 1236C>T(rs1128503), 2677G>T/A (2032562), 3435 C>T(1045642);CYP2C19 gene: CYP2C19*2 (rs4244285), CYP2C19*3 (rs4986893);CYP3A4 gene: CYP3A4*1B (392A>G: rs2740574); CYP3A4*18B (20070T>C; rs2242480);CYP3A5 gene: A6986G (rs776746);P2Y12 gene: 139C>T, 744T>C, 52G>T, 34C>T; | — |
Countries
China
Contacts
Public ContactXingyang Yi
Department of Neurology, Affiliated Deyang Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed