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Study of the increased risk of vascular dysfunction in offspring conceived under high maternal triglyceride

High maternal triglyceride can induce a general methylation alteration of the leptin gene of offspring that is associated with increased risk of vascular dysfunction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCH-14004536
Enrollment
Unknown
Registered
2014-04-17
Start date
2011-10-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High maternal triglyceride in utero

Interventions

high maternal triglyceride:none
control:none

Sponsors

Women Hospital, School of Medicine, Zhejiang University, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 50 Years

Inclusion criteria

Inclusion criteria: From the offspring undergoing health examination in Reproductive follow-up center, Zhejiang Women Hospital, we recruited the offspring born during 2006-2009 or offspring by random. We also recruited the group aged 7-14 (puberty) and aged 20-50 (adult) years old randomly from child care center and physical examination center of Hangzhou first people's hospital.

Exclusion criteria

Exclusion criteria: People born congenital malformation, formulti-fetal gestations,preterm birth, small-for-gestational age were not included. People with nephritis, nephrosis, chronic hypertention and other serious disease were also excluded.

Design outcomes

Primary

MeasureTime frame
leptin;blood biochemistry;—

Countries

China

Contacts

Public ContactHuang He-Feng

Women Hospital, School of Medicine, Zhejiang University

huanghefg@hotmail.com+86 13906526300

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026