AIDS
Conditions
Interventions
patients who met the second-line treatment criteria:Tenofovir (TDF) + Kaletra (ritonavir and lopinavir mixture) + lamivudine (3TC)combination antiretroviral therapy
patients who did not meet the second-line treatment:Tenofovir (TDF) + Kaletra (ritonavir and lopinavir mixture) + lamivudine (3TC)combination antiretroviral therapy
Sponsors
Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University
Eligibility
Sex/Gender
All
Age
32 Years to 60 Years
Inclusion criteria
Inclusion criteria: Referring to the 2007 version of the National Free ART Guideline.After first-line treatment failure happened(any of clinical,virological or immunological failure), the patients continued the old treatment for one month with rectified treatment compliance. After that, if the viral load of the patient was higher than 1000 copies/mL.The subjects had viral loads lower than 103 copies/mL, but they requested to switch to the second-line drugs due to significant toxicity and side effects of their first-line drugs.
Exclusion criteria
Exclusion criteria: HIV infected patients who did not receive first-line antiretroviral therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4+T lymphocyte;Viral load measurement;HIV Drug-resistant mutation; | — |
Countries
China
Contacts
Public ContactMin Zhang
The First Affiliated Hospital, China Medical University
Outcome results
None listed