chronic kidney disease
Conditions
Interventions
Sponsors
Nanjing General Hospital of Nanjing Military Command
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or Female patients 18 years old and elder; 2. Patients with ESRD receiving stable HD or PD at least 6 months; 3. Patient or legally accepted representitive willing to sign Consent Form.
Exclusion criteria
Exclusion criteria: 1. Patients' life expectancy <6 months; 2. Patients with acute kidney injury, active inflammatory diseases, parathyroidectomy or evident malignancies; 3. Patients with conditions making arterial calcification measurements technically impossible or unreliable, such as cardiac arrhythmias, amputations or severe peripheral vascular lesions; 4. Concomitant diseases that affect calcium status and soft tissue calcifications (sarcoidosis, multiple myeloma, HIV, amyloidosis); 5. Pregnant or lactating women or women planning to become pregnant in the 6 months following entry into the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In Chinese CKD patients undergoing HD or PD, to determine prevalence of CAC, AAC and cardiac valve calcification at baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate hazard ratio of all-cause/CVD mortality and non-fatal CV events to the risk factor of baseline VC including CAC, AAC and cardiac valve calcification at 24 months follow up;Hazard ratio of all-cause/CVD mortality and non-fatal CV events to the disease management including serum level of calcium, phosphorus and iPTH, and Different kind of phosphate binders including calcium-based binders, lanthanum-based binders, aluminum-based binders and sevelamer, Other calcium supplements, Vitamin D;Evaluate the impact of disease management (including serum level of calcium, phosphorus and iPTH, and medications), ABI, and LVMI/LVH on the occurrence and severities (scores) of CAC, AAC and cardiac valve calcification at baseline;Determine the percentage of patients achieving serum phosphorus, calcium and iPTH according to K/DOQI and KDIGO guidelines, respectively;Assess the sensitivity and specificity of CCI for predicting CAC; | — |
Countries
China
Contacts
Public ContactFan YANG
Outcome results
None listed