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A comparison of hemodynamic changes during endotracheal intubation, extubation and postoperative analgesia in hypertensive patients of different angiotension-converting enzyme genotypes

A comparison of hemodynamic changes during endotracheal intubation, extubation and postoperative analgesia in hypertensive patients of different angiotension-converting enzyme genotypes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCH-14004291
Enrollment
Unknown
Registered
2014-01-25
Start date
2011-01-19
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary hypertension

Interventions

DD:endotracheal intubation, extubation and postoperat
DI:endotracheal intubation, extubation and postoperat
II:endotracheal intubation, extubation and postoperat

Sponsors

Department of Anesthesiology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
51 Years to 67 Years

Inclusion criteria

Inclusion criteria: 737 patients with primary hypertension, who were scheduled for elective abdominal surgery under general anesthesia

Exclusion criteria

Exclusion criteria: secondary hypertension (e.g., hypertension due to hyperthyroidism or adrenal disease), anticipated difficulty in intubation (e.g., patients with a BMI greater than 30, bad teeth, limited mouth opening, reduced neck extension, Mallampati score of IV), poor left ventricular (LV) function, cardiac conduction abnormality, and permanent pacemaker in-situ.

Design outcomes

Primary

MeasureTime frame
angiotension-converting enzyme (ACE) genotypes;Hemodynamic response;

Countries

China

Contacts

Public ContactJun Wang

Department of Anesthesiology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi

wangjun19710930@126.com+86 13921113623

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026