Postoperative cognitive dysfunction
Conditions
Interventions
Laparoscopic:Laparoscopic
Sponsors
Department of Anesthesiology, The Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Aged 55 to 80 years, patients who are scheduled to undergo elective surgical procedures (major gastrointestinal surgery through laparoscopic or open approach) with Mini-Mental State Examination (MMSE) scores=24 and ASA I-III will be included in the study.
Exclusion criteria
Exclusion criteria: 1. patients with known central nervous system or major psychiatric disease,prior brain or other major surgery,significant cardiovascular disease, renal failure or active liver disease; 2. patients with vision dysfunction,auditory dysfunction,those who could not understand Chinese instructions or were otherwise unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6;HMGB1;TNF-a;8-isoprostane;s100ß protein;cognitive function; | — |
Countries
China
Contacts
Public ContactWen Ouyang
Department of Anesthesiology, The Third Xiangya Hospital, Central South University
Outcome results
None listed