Ischemic mitral regurgitation post first episode of myocardial infarction
Conditions
Interventions
ischemic MR:NA
non-ischemic MR:NA
control:NA
Sponsors
Research Grant Council
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Prospectively enrolled patients hospitalized for first episode of acute MI. 1. Diagnosis of MI is based on cardiac pain, newly developed Q waves, ST elevation/depression on ECG, and typical rise and fall of cardiac biomarkers (Troponin and/or CPK); 2. Patient will receive standard management for acute MI including medications and/or revascularization according to physician discretion; 3. All MI patients meeting the inclusion criteria will have serial transthoracic echocardiographic study including 2D/3D/TDI within 72 hours, in 7-14 days, and at 1 month post-MI. Patients will be separated into 2 groups based on presence or absence of IMR at 1 month, as defined by color flow imaging. The rationale of using 1 month for group separation is to avoid inclusion of transient MR due to acute ischemia, and is based on accepted definition of IMR in large epidemiological studies (2-4), as well as the time frame of ML adaptation in animal studies (13, 14, 17); 4. Healthy controls with normal history, physical examination and echocardiography matched for age, gender and body surface area will be enrolled from the community.
Exclusion criteria
Exclusion criteria: Prior MI or known left ventricular dysfunction, previous cardiac surgery, papillary muscle rupture, MR due to primary organic valve disease, associated aortic valve or congenital heart disease, poor image quality, and atrial fibrillation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mitral Regurgitation;symptoms;physicial examination;ECG;6 mins hall walk - secondary indicator;Treadmill exercise test - secondary indicator;Blood test - secondary indicato; | — |
Countries
China
Contacts
Public ContactDr. Alex Pui Wai LEE
Outcome results
None listed