lung cancer
Conditions
Interventions
mutation/wild-type:non-intervention
Sponsors
Shanghai Pulmonary Hospital, Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged >18 years; 2) Patients were diagnosed with histologically confirmed lung adenocarcinoma (Stage I-IIIA); 3) Patients harboring with EGFR wild type (over 98% NSCLC Pts are tested for EGFR mutations in our center); 4) ECOG status 0-2; 5) Patients have sufficient FFPE or fresh tissue available for HER-2/HER-4 mutations screening and validation; 6) DNA extracted from FFPE or fresh tissue was qualified for DNA sequencing; 7) The demongraphic data, including age, gender, smoking status, histological type and disease stage, are available for analysis; 8) Patients did not receive any therapy before operation or biopsy.
Exclusion criteria
Exclusion criteria: 1) Patients with other toumors; 2) Patients with other severe diseases, such as infectious diseases (viral hepatitis, HIV, etc); 3) Pregnant woman should be excluded; 4) Patients with severe mental illness that can not sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of HER-2 and HER-4 mutation positivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment choices;Disease free survival (DFS);Overall survival (OS);Toxicities;HER-2 and HER-4 mutation spectra;Other clinical charateristics and biomarke; | — |
Countries
China
Contacts
Public ContactZhou Caicun
Outcome results
None listed