infertility
Conditions
Interventions
None listed
Sponsors
Nil
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Polycystic ovary syndromeThirty women with PCOS and clinical indication for endometrial biopsy for histological examination (e.g. infertility, abnormal vaginal bleeding or increase endometrial thickness) will be recruited as study subjects. The diagnosis of PCOS is based on the latest 2003 Rotterdam consensus with at least two of the following features: (i) oligo-amenorrhoea or chronic anovulation, (ii) clinical and/or biochemical hyperandrogenism, (iii) ultrasound appearance of polycystic ovaries, after exclusion of other known causes of hyperandrogenaemia2.(2) ControlAnother thirty age- and body mass index (BMI) matched women without PCOS, who with clinical indication for endometrial biopsy for histological examination (e.g. infertility, abnormal vaginal bleeding or increase endometrial thickness) will be recruited as control subjects. All of them has regular menstrual cycles and has no hirsutism/acne or ultrasound features of polycystic ovaries.3.Women with PCOS with clinical indication for endometrial biopsy (e.g. infertility, abnormal vaginal bleeding or increase endometrial thickness) will be recruited as study subjects. The diagnosis of PCOS is based on the latest 2003 Rotterdam consensus with at least two of the following features: (i) oligo-amenorrhoea or chronic anovulation, (ii) clinical and/or biochemical hyperandrogenism, (iii) ultrasound appearance of polycystic ovaries, after exclusion of other known causes of hyperandrogenaemia2.4.Patients should not receive any treatments for PCOS within 3 months before our study
Exclusion criteria
Exclusion criteria: 1. Present of endocrinological or autoimmune disease 2. Usage of medications which are known to affect steroid or glucose metabolism (e.g. oral contraceptives, corticosteroids) within the past 3 months 3. Smoker or drinker 4. Refuse participation of study or incompetence to make informed consent.
Countries
China
Contacts
Public ContactDr. Wai Yee Wong
Outcome results
None listed