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Clinical study on relationship of platelet beta amyloid changes and postoperative cognitive dysfunction

Clinical study on relationship of platelet beta amyloid changes and postoperative cognitive dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCH-12002348
Enrollment
Unknown
Registered
2012-07-12
Start date
2011-02-07
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

postoperative cognitive dysfuction group:operation
none-postoperative cognitive dysfunction group:operation

Sponsors

Shanghai Pudong Gongli Area
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 79 Years

Inclusion criteria

Inclusion criteria: ASA I-II More than 65 years old; General anesthesia for elective non-cardiac surgery; 0peration time between 2-4 hours

Exclusion criteria

Exclusion criteria: Central nervous system diseases and mental illness; Diseases of the blood system; Platelet abnormalities; Long-term use of sedative and antidepressant drugs; Serious liver and kidney dysfunction; Illiteracy and other causes can not be effectively communicate with the psychiatrist; Preoperative Mini Mental State (MMSE) score <23 points; Drug dependence or alcohol abuse.

Design outcomes

Primary

MeasureTime frame
cognitive function;beta-amyloid;amyloid precursor protein ratio;alpha-secretase enzyme;Beta-secretase enzym;—

Countries

China

Contacts

Public ContactWan Yanjie
yanjie.wan@yahoo.com.cn+86 13918045388

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026