Effect of liver function on pharmacokinetics and pharmacodynamics of propofol

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OCH-12002255

Enrollment

Unknown

Registered

2012-04-20

Start date

2012-06-11

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver function

Interventions

normal:concentration and pharmacodynamic parameters

Child-Pugh A:concentration and pharmacodynamic parameters

Child-Pugh B:concentration and pharmacodynamic parameters

Child-Pugh C:concentration and pharmacodynamic parameters

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 80 patients age 18~50 who need elective surgery (gastrointestinal,Hepatobiliary) with normal renal function, including normal liver function 20 patients, Child-Pub A 20 patients, Child-Pub B 20 patients, and Child-Pub C 20 patients.

Exclusion criteria

Exclusion criteria: Patients with renal insufficiency or mental, neurological disease or taking the appropriate drugs.

Design outcomes

Primary

Measure	Time frame
BIS;heart rate;BP;concentration;	—

Countries

China

Contacts

Public ContactZiqing Hei

Third Affiliated Hospital, Sun Yat-sen University

heiziqing@sina.com+86 20 13925020330

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 28, 2026