The clinical significance of NBNA scoring and brainstem auditory evoked potential and neuron-specificenolase and S100beta portein in assessing the neurotoxicity of sevoflurane on neonates during early postoperative stage

Effect of NBNA scoring and brainstem auditory evoked potential and neuron-specificenolase and S100beta portein in neonates after sevoflurane inhalation anesthesia during the early postoperative stage

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OCH-12002169

Enrollment

Unknown

Registered

2012-05-12

Start date

2009-12-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the neurotoxicity of neonates with sevoflurane exposure

Interventions

Cet-sev × hour <=3.3% group:sevoflurane exposure

3.3%<Cet-sev × hour <6.6%:sevoflurane exposure

6.6%<=Cet-sev × hour group:sevoflurane exposure

neonates without undergoing operation:non sevoflurane exposure

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: ASA I or II,getation with 37-42 weeks, birth weight not less than 2500, postnatal 1mins and 5min-s Apgar scores not less than 8,male or female neonates undergoing gastrointestinal operations.

Exclusion criteria

Exclusion criteria: 1. premature infant; 2. neonates undergoing perinatal asphyxia or hyperbilirubinemia or hypoxic-ischemic encephalopathy; 3. neonates with Down's disease, intracranial infction, intracranial hemo-rrhage, ear diseases and history of administration of ototoxicity drugs.

Design outcomes

Primary

Measure	Time frame
Neonatal Behavioral Neurological A-ssessment, NBN;brainstem auditory evoked potential;neuron-specificenolase;S100beta protein;	—

Countries

China

Contacts

Public ContactGuo-lin Lu

drguolinlu@163.com+86 13859031635

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026