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Mutations of hepatitis B virus increase the risk of hepatocelluar carcinoma in chronic hepatitis B patients: a cohort study

Mutations of hepatitis B virus increase the risk of hepatocelluar carcinoma in chronic hepatitis B patients: a cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCH-12002077
Enrollment
Unknown
Registered
2012-03-21
Start date
1999-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis B, hepatocelluar carcinoma

Interventions

exposure group:CHB patients with HBV
control group:CHB patients with wild type HBV

Sponsors

Department of Epidemiology, Second Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 71 Years

Inclusion criteria

Inclusion criteria: 1. chronic hepatitis B patients; 2. complete baseline information; 3. patients signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients had autoimmune or genetically induced (hemochromatosis, Wilson's disease or a1-antitrypsin deficiency) liver disease; 2. injection drug users; 3. co-infection with other hepatitis virus except hepatitis B virus, or human immunode?ciency virus; 4. other causes of liver disease, such as autoimmune hepatitis, and primary biliary cirrhosis; 5. advanced liver diseases, such as decompensated cirrhosis, severe hepatitis, and hepatic carcinoma.

Design outcomes

Primary

MeasureTime frame
liver function;hepatitis B virus mutations;HBV genotype;a-fetoprotein;ultrasonograph B;computed tomograph;—

Countries

China

Contacts

Public ContactCao Guangwen, Yin Jianhua and Ni Wu
gcao@smmu.edu.cn+86 21 81871060

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026