Inflammatory gene polymorphisms and vivo metal ion concentration in the risk assessment of aseptic loosening of metal on metal total hip arthroplasty

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-OCH-12001898

Enrollment

Unknown

Registered

2012-01-30

Start date

2011-01-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

total hip arthroplasty

Interventions

prosthesis loosening:NA

Eligibility

Sex/Gender

All

Age

21 Years to 89 Years

Inclusion criteria

Inclusion criteria: 1. suffered from femoral neck fracture, avascular necrosis of the femoral head, osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, hip joint ankylosis, located in the femoral head and neck or acetabular low-grade malignant swelling, or DDH pain, influence of joint function. In my Department of artificial total hip arthroplasty; 2. liver, normal renal function; 3. agreed to participate in this study.

Exclusion criteria

Exclusion criteria: 1. acute and chronic local or systemic infection; 2. for implant materials of allergy, especially metal (such as cobalt, chromium, nickel, etc.); 3. renal insufficiency; 4. highly malignant tumor bone metastasis; 5. pregnancies

Design outcomes

Primary

Measure	Time frame
Inflammatory gene polymorphisms;Cobalt ion;Chromium ion;Manganese ion;	—

Contacts

Public ContactYang Liu

jointsurgery@163.com+86 13908399739

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026