living kidney transpplantation
Conditions
Interventions
observation group:200 living renal donors and recipients
Sponsors
Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: In addition to the conformity of donor-recipient relationships to legislations, the following four basic evaluations should be included: 1. Risk is low for the donor. 2. The donor is completely informed. 3. The donor is voluntary without indications or coercion. 4. High likelihood for the recipient to have a good prognosis. The donor and recipient were linear blood relatives, adjacent consanguinities within three generations, couples or relatives formed by financial support. Before operation, all the relationships should be accredited by law and approved by the ethic committee of the hospital. Inclusion criteria of physiological examination: 1. The blood types were conformed to the blood transfusion principle; 2. The subjects were adults with independent behavioral ability, that is, those aged above 18, without psychiatric disorders; 3. Self-reported healthy individuals without past history of severe cardiovascular diseases, renal diseases, infectious diseases and diabetes mellitus, as well as malignant tumors.
Exclusion criteria
Exclusion criteria: Exclusion criteria of physiological examinations: 1. The fasting blood glucose or glucose tolerance was impaired; 2. Those with systolic blood pressure more than 140 mmHg or diastolic blood pressure more than 90 mmHg in consecutive three days measured twice at different hour every day, and the blood pressure could not be controlled below 140 mmHg/90 mmHg with single antihypertensive agent; 3. Those found to have malignant tumors or undetermined occupied lesions; 4. Those identified to be the carriers of HBV, or infected with HBV, HCV, syphilis, and HIV; 5. Those with abnormal renal functions, presented as elevated creatinine and urea nitrogen, more than 150 mg of the 24 h urine protein quantification, GFR< 70ml/min detected by nuclide, persistent microscopic blood urine with malformed RBC more than 10000 / ml in three urinary RBC phase tests; 6. Those with diseases of cardiovascular or hematological systems that might influence the operation; 7. Those with bilateral urinary calculi or unilateral calculi that significantly impaired ipsilateral renal function; 8. Those with positive lymphocytotoxic test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quantitation of decoy cell under light microscope, amplification of PCR (BK virus);BMI,BP,urine protein,microscopic blood urine;biopsy of renal graft;serum creatinine;cystatinc;SF-36 health survey scale; | — |
Countries
China
Contacts
Public ContactLizhong Chen
Outcome results
None listed