leukemia
Conditions
Interventions
CAR-T group:CAR-T therapy
Sponsors
Bone marrow transplantation center,first affiliated hospital of Zhejiang University,school of medicine
Eligibility
Sex/Gender
All
Age
No minimum to 60 Years
Inclusion criteria
Inclusion criteria: 1. CD19 positive acute leukemia: (1) cases of CD19 positive ALL/lymphoma with relaps, refractoriness or durg risistence; (2) high tumor load before aHSCT; (3) failed DLI for relapse after aHSCT; (4) relapsed refractory MRD positive cases; (5) extramedullary leukemia failed for chemotherapy/radiotherapy; 2. aged 0-60; 3. expected survival beyond 6 months; 4. urine pregnancy test negative for fertile women,and agree to take contraception during the trial; 5. voluntarily anticipated the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. medical history of epilepsy or other disease of central nervous system; 2. case of GVHD using immunosuppressant; 3. medical history of prolonged QT period or other severe heart disease; 4. pregnancy or lactation; 5. uncured active infection; 6. active HBV/HCV infected; 7. steroid drug users in 2 weeks; 8. gene therapy product ever used; 9. transfection efficiency lower than 30%, or low amplification (2.5mg/dl or ALT/AST>3 fold standard value or bilirubin>2.0 mg/dl; 11. any uncured disease considered unavailable for the trial; 12. HIV infected; 13. any condition may increase volunteer's risk or interference the outcome of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimal residual diseas;remission rate; | — |
Countries
China
Contacts
Public ContactHe Huang
Outcome results
None listed