hematologic malignance
Conditions
Interventions
Case series:Related HLA-haploidentical/mismatched allogeneic non T cell-depleted in vitro peripheral blood hematopoietic stem cell transplantation
Sponsors
Hematologic disease center,First Affiliated Hospital of XinJiang Medical University
Eligibility
Sex/Gender
All
Age
15 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1) Age: 15 to 50 years old; 2) Confirmed diagnosis hematological malignancies, including: ALL in initial treatment (standard risk and high risk group), AML in initial treatment?except M3 (moderated and high risk group), MDS (IPSS up 3.5), recurrence of refractory ALL and AML(note: use a IPSS MDS - R scoring system); 3) HLA-matching all used high resolution genotyping and choose 2/6 or 3/6 HLA-halpltype (HLA - A, B and DRB1); 4) Patiens haven't severely organ injury of heart, lung, kidney, only mild damage to liver function (Child class A); 5) The following feasible transplantation: patients with hepatitis b virsus, hepatitis c virsus of not actively liver damage and strict monitoring viral replication in normal copy number; with TB infection of infected has been control, under continue to anti-TB treatment; patients have?fungal infection?recently of full control of infected site; 6) All volunteer signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) There is difficult to control the active infection; 2) Patients have organ injury of heart, lung, kidney and severe liver damage (Child class B, C); 3) Pregnancy; 4) Mental illness; 5) Patients don't sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute graft versus host disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic graft versus host disease;Engraftment;Overall Surviver;disease free survival;transplantation related mortality; | — |
Countries
China
Contacts
Public ContactMing Jiang
Outcome results
None listed