radiation induced lung injury
Conditions
Interventions
RILI grouo and non-RILI group :Nil
Sponsors
People's Liberation Army 251th Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. All patients had pathologically or cytologically proven lung cancer,received 3D-CRT or IMRT; 2. All patients are fully informed and sign informed consent; 3. No history of receiving surgical intervention; 4. Without serious heart and lung diseases, liver and kidney function damage before radiation; 5. The score is more than 80 points of Karnofsky performance status and less than 80 years old; 6. All patients treated with concurrent or sequential chemoradiotherapy; 7. The survival is more than 6 months.
Exclusion criteria
Exclusion criteria: 1. The patients receiving re-irradiation therapy; 2. The D95 prescription is less than 50Gy; 3. Forced expiratory volume in 1 sec(FEV1) is less than 1.5L, forced expiratory volume in the first second in percent of expected value (FEV1%) and diffusing capacity of the lung for carbon monoxide expressed in percent of the predicted value (DLCO%) are both less than 60%; 4. The patients can't tolerate or give up radiation therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary Function;Dosimetry parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;IL-8;TGF-beta 1;MMP-2; | — |
Countries
China
Contacts
Public ContactWang Bingsheng
Outcome results
None listed