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Assessment the immune dysfunction and organ injury of severe sepsis patients

Assessment the immune dysfunction and organ injury of severe sepsis patients

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCC-14005202
Enrollment
Unknown
Registered
2014-09-09
Start date
2014-09-15
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Control:none
ICU Control:none
Sepsis:none
Severe sepsis:none
Septic shock:none

Sponsors

Emergency Medical Department of ZhongShan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Meet the dignostic criteria of severs sepsis or septic shock; 2. patients or his/her family members sign the informed consent; 3. To be aged 18 to 85 years; 4. not allergic to steroids and thymosin; 5. do not have a history of psychiatry disease.

Exclusion criteria

Exclusion criteria: 1. pregnant; 2. age beyond 85 or under 18; 3. patients or family members do not agree to participate in the trial; 4. taking steroids or other medicines that influence immune systems (ie thymosin,recombinant Human Granulocyte Colony Stimulating Factor) for more than 6 months; 5. co-exist serious organ disfunction due to other diseases rather than severe sepsis or septic shock; 6. end stage of malignant tumor or terminal illness.

Design outcomes

Primary

MeasureTime frame
ICU or 28th-day mortalit;—

Secondary

MeasureTime frame
function of major organs (heart, lung, liver, kidn;IL-1 beta;TNF-alpha;IL-2R;IL-6;IL-8;MCP-1;IL-4;IL-10;the count and type of Lymphocytes (CD4+, CD8+, CD4;expression of mHLA-DR;—

Countries

Shanghai

Contacts

Public ContactZhenju Song
Song.zhenju@zs-hospital.sh.cn+86 13816607453

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026