postoperative cognitive dysfunction
Conditions
Interventions
Anesthesia time longer than 8 hours:N/A
Anesthesia time longer than 4 hours and shorter than 8 hourse:N/A
Sponsors
Shanghai Ninth People's Hospital Afflicated Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: The cognitive function test can be completed by educational level and willingness to cooperate, and reported to the Hospital Ethics Committee.
Exclusion criteria
Exclusion criteria: Younger than 60 years old, before operation a score on the mini-mental state examination (MMSE) at screening of 23 or less; a sc-ore on the self-rating depression scale (SDS) at screening of 50 or more;a disease of the central nervous system; were taking tranquillisers or antidepressants; had been admittedfor neurological or cardiac surgery; previously undergone neuropsychological testing; were unwilling to comply with the protocol or procedures or were unable to understand the language used; had any severe visual or auditory disorders; were illiterate; had Parkinson's disease; alcoholism, or drug dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mini-mental state examination;self-rating depression scale;Beta-amyloid protein 1-40;S-100 beta protein; | — |
Countries
China
Contacts
Public ContactHui Xu
Outcome results
None listed