colorectal cancer
Conditions
Interventions
Case (colorectal cancer) group:a newly diagnosed colorectal cancer( CRC ) by colonoscopy and pathology
Control group:Clinically healthy volunteers with no symptoms or history of intestinal disease(e.g. colonic adenomatous polyps, CRC or inflammatory bowel disease)
Sponsors
Medical College of Qingdao University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: For case group: 1.Consecutive outpatients suffering from a newly diagnosed colorectal cancer(CRC) by colonoscopy and pathology; 2.Both males and females, aged 30-70 years; 3.No previous history of colon or rectal surgery, of diseases such as cancer, or of inflammatory or infectious injuries of the intestine; 4.None familial adenomatous polyposis or hereditary nonpolyposis colon cancer; 5.Have mental competency to complete the interview; 6.All individuals will provide written informed consent prior to participating in the study; 7.A detailed information on frequency of consumption of specific foods, food groups, and micronutrients, will be collected by interview; 8.Willing to collect 2 spontaneously passed fresh stool samples between 2 and 4 weeks after the diagnostic colonoscopy and biopsies, and before starting pre-operative preparation with bowel cleansing and with oral antibiotics. For control group: 1.Clinically healthy volunteers with no symptoms or history of intestinal disease(e.g.colonic adenomatous polyps, CRC or inflammatory bowel disease); 2.Being matched for age and sex to the case group; 3.No family history of CRC in first-degree relative; 4.Body mass index(BMI) between 20 and 28 kg/m^2; 5.Subjects giving his/her written informed consent; 6.A detailed information on frequency of consumption of specific foods, food groups, and micronutrients, will be collected by interview; 7.Willing to collect 2 spontaneously passed fresh stool samples.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Inability to provide informed consent; 3.The use of antibiotics within 1 month before stool sampling; 4.The use of prokinetic drugs and probiotics including yoghurt within 1 month before stool sampling; 5.Regular use of aspirin and/or nonsteroidal anti-inflammatory drugs; 6.Undergone chemotherapy or radiation treatments before sampling; 7.Current infection with an enteric pathogen; 8.Overt gastrointestinal bleeding within 1 month (including due to suspected hemorrhoids); 9.Chronic diarrhea, inflammatory bowel disease, recurrent colorectal cancer, irritable bowel syndrome, or other gastrointestinal disorder, gastrointestinal surgery (e.g.colectomy, proctectomy or cholecystectomy ), severe chronic diseases such as major organ failure,other malignant diseases,diabetes mellitus; 10.Body mass index(BMI) >= 28kg/m^2; 11.Time interval between colonoscopic biopsy and operation less than two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composition of gut microbiota;intestinal microbial phytase activity;16s rRNA metagenomic sequencing;diet surveys;phytic acid intake; | — |
Secondary
| Measure | Time frame |
|---|---|
| dietary fiber intake; | — |
Countries
China
Contacts
Public ContactYang Song
Medical College of Qingdao University
Outcome results
None listed