Epilepsy
Conditions
Interventions
Newly diagnosed epileptic patients:AEDs
Control:None
DR epileptic patients:AEDs
WH epileptic patients:AEDs
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 64 Years
Inclusion criteria
Inclusion criteria: The common inclusion criteria were: (1) patients with a definite diagnose of epilepsy with partial secondary generalized seizures. The types of epilepsy and the seizure types were defined according to the International League Against Epilepsy (ILAE) [34, (1989) Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 30: 389-399.]; (2) patients willing to participate in this study. The idiosyncratic inclusion for newly diagnosed epileptic patients were (1) patients who never received AEDs; (2) the time from patients suffered from first seizure attack to they came to us was less than 3 months. The idiosyncratic inclusion for DR epileptic patients was patients with frequently seizure onsets (more than four seizures per month) and refractory to maximal doses of four AEDs, including Valproate, Carbamazepine, Topiramate, Lamotrigine or Levetiracetam. The idiosyncratic inclusion criteria for WH patients: (1) patients without seizure onsets for contiguous 5 years at least; (2) no epileptic wave had been found from the last Holter monitoring electroencephalogram scans before we prepared to stop medicine.
Exclusion criteria
Exclusion criteria: The exclusion criteria were: (1) patients with focal abnormality in the structure MRI; (2) patients with progressive central neurological diseases or tumor; (3) patients with only acute symptomatic or non-epileptic seizures; (4) patients with a history of psychiatry or mood problems; (5) patients with neurological deficiencies, such as hearing or visual loss; (6) patients suffering from intolerable adverse events during follow up; (7) patients who lost to follow up; (8) patients fearing confined spaces; (9) patients with a head motion larger than 2.5mm translation or 2.5 degree rotation when scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fALFF;FA; | — |
Countries
China
Contacts
Public ContactWang Xuefeng
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed