Surgical patients
Conditions
Interventions
Sponsors
The Third Xiangya Hospital Of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Local anesthesia patients aged 18-40 years and 65-75 years
Exclusion criteria
Exclusion criteria: 1. severe bradycardia (heart rate \50 beats/min); 2. uncompensatedacute circulatory failure at time of randomisation; 3. atrioventricular-conduction block II–III (unless pacemaker installed); 4. Patients with significant haematological, endocrine, metabolic, or gastrointestinal disease were excluded; 5. use of centrally acting a2 agonists or antagonists; 6. Patients with a history of intolerance to dexmedetomidine or related compounds and additives; 7. Subjects with human immunodeficiency virus (HIV), hepatitis B, hepatitis C; 8. Pregnancy, lactation Women; 9. Patients with donation of blood or collection of plasma sample in 3 months before the dose of the study; 10. investigators' own judgement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Drug Concentration; | — |
Countries
China
Contacts
Public ContactGuoping Yang, Kaiming Duan, Saiying Wang
The Third Xiangya Hospital Of Central South University
Outcome results
None listed