pneumonia
Conditions
Interventions
study group:draw blood
control group:draw blood
Sponsors
Pudong Health Bureau of Shanghai
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged >=65 years were included in the study; 2. Severe CAP, HCAP or VAP were diagnosed according to the modified American Thoracic Society guidelines if the patient fulfilled 1 major or 3 minor criteria: (i) Major: septic shock or need for ventilation; (ii) Minor: respiratory rate >=30 breaths/min; multilobar infiltrates (>2 lobes); confusion/disorientation; uremia (BUN level >=20 mg/dL); leukopenia (WBC count <4000 cells/mm3); thrombocytopenia (platelet count <100,000 cells/mm3); hypothermia (core temperature <36 degree C); hypotension requiring aggressive fluid resuscitation; or PaO2/FiO2 ratio <=250; 3. Sign the informed consent document.
Exclusion criteria
Exclusion criteria: 1. Patients aged >=65 years were included in the study; 2. Severe CAP, HCAP or VAP were diagnosed according to the modified American Thoracic Society guidelines if the patient fulfilled 1 major or 3 minor criteria: (i) malignancies and known haematological disease; (ii) immunological diseases; (iii) likely to die within 48 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toll-like receptor 2;Toll-like receptor 4;mortality rate after 28 day; | — |
Countries
China
Contacts
Public ContactTang lunxian
Outcome results
None listed